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Abstract Title:

Echinacea Angustifolia DC Extract Induces Apoptosis and Cell Cycle Arrest and Synergizes with Paclitaxel in the MDA-MB-231 and MCF-7 Human Breast Cancer Cell Lines.

Abstract Source:

Nutr Cancer. 2020 Sep 22:1-19. Epub 2020 Sep 22. PMID: 32959676

Abstract Author(s):

Daniel Abraham Espinosa-Paredes, Jorge Cornejo-Garrido, Mario Adán Moreno-Eutimio, Oswaldo Pablo Martínez-Rodríguez, María Eugenia Jaramillo-Flores, Cynthia Ordaz-Pichardo

Article Affiliation:

Daniel Abraham Espinosa-Paredes

Abstract:

BACKGROUND: displays different biological activities, such as antiviral, immunomodulatory, and anticancer activities. Currently, high sales of hydroalcoholic extracts ofhave been reported; hence, the importance of studies on.

AIM: To establish the effects ofDC extract obtained with ethyl acetate (-AcOEt) in breast cancer cell lines.

METHODS: Cytotoxicity, cell cycle arrest, and cell death were evaluated. Besides, the safety of the extract, as well as its effect in combination with paclitaxel were investigated.

RESULTS: The echinacoside and caffeic acid content in the-AcOEt extract were quantified by HPLC, and its antioxidant activity was assessed. The-AcOEt extract showed cytotoxic activity on breast cancer MDA-MB-231 cells (IC28.18 ± 1.14 µg/ml) and MCF-7 cells (19.97 ± 2.31 µg/ml). No effect was observed in normal breast MCF-10 cells. The-AcOEt extract induced cell cycle arrest in the G1 phase and caspase-mediated apoptosis. No genotoxicity was foundor, and the extract showed no signs of toxicity or death at 2,000 mg/kg in rodents. In vitro, the combination of-AcOEt extract and paclitaxel showed a synergistic effect on both cancer cell lines.

CONCLUSION: The-AcOEt extract is a potential candidate for breast cancer treatment.

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