Synergetic effects of oral administration of levamisole and Echinacea purpurea on immune response in Wistar rat.
Res Vet Sci. 2010 Aug 24. Epub 2010 Aug 24. PMID: 20797737
Scientific Association of Veterinary Medicine, Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch, Tabriz, Iran.
This research investigated the effects of levamisole and Echinacea purpurea (EP), separately and together on the immune response of the rat as a laboratory model. In this experiment, 40 male Wistar rats were obtained and divided into four groups (n=10). These groups received normal saline (10mg/kg), EP (500mg/kg), levamisole (2mg/kg) and EP (500mg/kg) with levamisole (2mg/kg) as oral gavages every day for a period of 4weeks, respectively. After obtaining blood samples (at the end of each week), haematocrit (HCT), differential and total white blood cell (WBC) counts, phagocyte activity (number), total protein, albumin and globulins levels of samples were obtained. The results of the study showed that the gamma globulin level, WBC, neutrophil and monocyte counts and phagocyte activity increased significantly in comparison with normal saline group during the study. According to the results, each of the mentioned agents had a stimulant effect on the immune system separately and together on rats. In the group that received EP and levamisole simultaneously, these effects were synergistically increased. These compounds, by increasing the mentioned factors, will probably affect the immune system.