Abstract Title:

Bioencapsulation of the hepatitis B surface antigen and its use as an effective oral immunogen.

Abstract Source:

Vaccine. 2012 Apr 19 ;30(19):2937-42. Epub 2012 Mar 8. PMID: 22406456

Abstract Author(s):

Celine A Hayden, Stephen J Streatfield, Barry J Lamphear, Gina M Fake, Todd K Keener, John H Walker, John D Clements, Debra D Turner, Ian R Tizard, John A Howard

Article Affiliation:

Applied Biotechnology Institute, Cal Poly Tech Park, San Luis Obispo, CA 93407, United States.


Hepatitis B remains a major global health problem despite the availability of a safe and effective vaccine. Segments of the population lack access to or respond poorly to the parenteral vaccine, perpetuating the infection-transmission cycle. A low cost, orally delivered vaccine has the potential to alleviate many of these problems. Here we describe the expression of a bioencapsulated hepatitis B surface antigen (HBsAg) in maize and its immunogenicity, demonstrating for the first time a commercially feasible oral subunit vaccine production system for a major disease. This work surmounts previous barriers to plant-produced vaccines by expressing HBsAg at much higher levels and retaining antigen immunogenicity post-processing: factors which facilitated a robust immune response in mice without the need for an adjuvant. This method provides a practical solution to the delivery of a low-cost, stable oral vaccine.

Study Type : Review
Additional Links
Additional Keywords : Edible Vaccines : CK(17) : AC(0)

Print Options

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.