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Abstract Title:

The Effect of Dietary Antioxidant Supplementation in Patients with Glaucoma.

Abstract Source:

Clin Ophthalmol. 2021 ;15:2293-2300. Epub 2021 Jun 2. PMID: 34113073

Abstract Author(s):

Noriko Himori, Maki Inoue Yanagimachi, Kazuko Omodaka, Yukihiro Shiga, Satoru Tsuda, Hiroshi Kunikata, Toru Nakazawa

Article Affiliation:

Noriko Himori

Abstract:

Purpose: Oxidative stress may be a risk factor for glaucoma, and many previous reports have suggested that antioxidants could be a promising treatment. Here, we investigated the effects of a novel supplement containing three food-derived antioxidants (hesperidin, crocetin, and) on markers of oxidative stress in patients with glaucoma.

Patients and Methods: This study had a prospective, single arm design. Thirty Japanese glaucoma patients were recruited and given 4 tablets with ample water twice a day for 8 weeks. The treatment was stopped, and the subjects were followed for an additional 8 weeks. We measured biological antioxidant potential (BAP) with a free radical analyzer. We also measured urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG; a marker of oxidative DNA damage). Clinical laboratory data were measured in venous blood samples. Clinical parameters were also recorded. Comparisons used a one-way analysis of variance (ANOVA) followed by Dunnett's test.

Results: The 8-OHdG level was not reduced. We also divided the patients into groups with high or low oxidative stress. In patients with relatively high oxidative stress, the 8-OHdG level was significantly reduced at weeks 4, 8, 12, and 16 (<0.001,<0.01,<0.01,<0.01), and BAP was significantly elevated at weeks 8 and 12 (= 0.03,= 0.04). In patients with relatively low oxidative stress, the 8-OHdG level was not significantly reduced during supplement intake but was significantly elevated at weeks 12 and 16 (=0.03,= 0.04), while BAP was not significantly elevated.

Conclusion: An 8-week oral course of antioxidant supplementation was effective in patients with a high oxidative stress level. Dietary supplementation could hold promise in the treatment of systemic oxidative stress-related diseases.

Study Type : Human Study

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