n/a
Article Publish Status: FREE
Abstract Title:

The Effect of Grape Products Containing Polyphenols on C-reactive protein Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Abstract Source:

Br J Nutr. 2020 Sep 14:1-41. Epub 2020 Sep 14. PMID: 32921322

Abstract Author(s):

Sahar Sarkhosh-Khorasani, Mahdieh Hosseinzadeh

Article Affiliation:

Sahar Sarkhosh-Khorasani

Abstract:

Although grape polyphenols can decrease chronic inflammations, their effect on C-reactive protein (CRP) levels is still controversial. So, this meta-analysis was conducted to investigate the effect of grape products containing polyphenols on CRP concentrations. In order to collect the relevant randomized controlled trials (RCTs), the data bases of PubMed, Scopus, Web of Science, and Google Scholar were searched up to March 30, 2020. The random-effects model, standardized mean difference, and 95% confidence interval were applied in data analysis. Meta-analysis was conducted over 17 eligible RCTs containing a total of 668 participants. The study registration number is CRD42018110169. Based on the results, grape products containing polyphenol decreased the CRP levels significantly (SMD = -0.229; 95% CI: -0.41, -0.05; P = 0.013). The sensitivity analysis was performed by removing each individual study and the results did not change. According to the subgroup analysis, higher doses of grape polyphenols (˃ 500 mg/d) and longer intervention periods (≥ 12 wk) had significant effects on CRP levels. Furthermore, grape polyphenols significantly reduced the CRP levels in patients with a clinical condition. In the same vein, grape seed extract and other grape products, such as grape extract, juice, andraisin, decreased the CRP levels significantly. According to the meta-regression results, the CRP level depends on the dose and duration of the grape polyphenols supplementation. Based on the findings, grape products containing polyphenols had a significant effect on CRP levels. Further well-designed and long-term clinical trials are highly recommended to achieve more comprehensive and accurate results.

Study Type : Meta Analysis, Review

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.