n/a
Abstract Title:

The Effect of Grape Seed Extract Supplementation on Oxidative Stress and Inflammation─ A Systematic Review and Meta-Analysis of Controlled Trials.

Abstract Source:

Int J Clin Pract. 2021 Jun 9:e14469. Epub 2021 Jun 9. PMID: 34107109

Abstract Author(s):

Sahar Foshati, Mohammad Hossein Rouhani, Reza Amani

Article Affiliation:

Sahar Foshati

Abstract:

Grape seed extract (GSE) seems to have antioxidant and anti-inflammatory properties due to its high polyphenolic content. Nevertheless, the scientific literature in this field is controversial and inconclusive. Therefore, we aimed to conduct a systematic review and meta-analysis of controlled trials to evaluate the effect of supplementation with GSE on biomarkers of oxidative stress and inflammation. Medline, Scopus, Cochrane Library, Google Scholar, and Web of Science databases were searched up to September 10, 2020 using appropriate keywords without restrictions. 23 studies were included in the systematic review, and 19 studies were included in the meta-analysis. GSE supplementation caused a significant decrease in malondialdehyde (SMD: -1.04, 95% CI: -1.65, -0.42), oxidized low-density lipoprotein (SMD: -0.44, 95% CI: -0.75, -0.13), and high-sensitivity C-reactive protein (WMD: -0.48 mg/L, 95% CI: -0.94, -0.03) and a marginally significant increase in total antioxidant capacity (SMD: 0.49, 95% CI: -0.05, 1.04) but did not significantly influence C-reactive protein (WMD: -0.36 mg/L, 95% CI: -1.02, 0.30) and white blood cell count (WMD: 0.12× 10/L, 95% CI: -0.25, 0.48). It appears that GSE supplementation can remarkably modulate the body's redox system, particularly through the inhibition of lipid peroxidation, but has neutral or mildly beneficial effects on inflammatory responses.

Study Type : Meta Analysis, Review

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.