n/a
Abstract Title:

The effect of high fat, high sugar, and combined high fat-high sugar diets on spatial learning and memory in rodents: A meta-analysis.

Abstract Source:

Neurosci Biobehav Rev. 2019 Aug 24. Epub 2019 Aug 24. PMID: 31454627

Abstract Author(s):

Kirsten N Abbott, Christopher K Arnott, R Frederick Westbrook, Dominic M D Tran

Article Affiliation:

Kirsten N Abbott

Abstract:

Evidence from human and animal studies suggests that high-energy diets impair cognitive function. However, the conditions for such impairments are unclear as studies have differed in the type and duration of diet exposure as well as in the tasks used to assess deficits in cognition. Here, we focused on hippocampal-dependent tasks. We conducted separate meta-analyses of the results from rodent studies using: 1) different diets (high in fat, high in sugar, or high in both fat and sugar); and 2) different tasks to assess hippocampal-dependent spatial learning and memory (water maze, place recognition, radial arm maze, and spontaneous alternation). We focused on the effects of relatively short-term dietary manipulations and, therefore, restricted our analyses to studies that provided the diet for two months or less. The meta-analyses showed that each type of diet and task adversely affected performance, with the largest effect produced by exposure to a combined high fat-high sugar diet and the use of the radial arm maze to assess the effect of such diets on cognition.

Study Type : Meta Analysis

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.