Effect of isgin (L.) on biochemical parameters, antioxidant activity and DNA damage in rats with obesity induced with high-calorie diet.
Arch Physiol Biochem. 2020 Sep 12:1-9. Epub 2020 Sep 12. PMID: 32924615
The present study was designed to investigate the effects ofL. plant root extracts on DNA damage, biochemical and antioxidant parameters in rats with experimental obesity induced with a high-calorie diet. The study groups were divided as"normal control(NC)","obese control(OC)","obese +(OR1)(200 mg/kg)"and"obese +(OR2)(400 mg/kg)". At the end of the application, rats were sacrificed and blood and tissue samples were obtained. According to the results obtained, the marker of DNA damage in tissues of 8-OHdG was determined to be significantly reduced in brain tissue of the OR1 and OR2 groups compared to the NC group. However, fluctuations were identified in the MDA activity, antioxidant defense system elements and serum biomarkers in tissues. In conclusion,plant root extract ensured improvements in DNA damage in brain tissues and MDA levels and showed positive effects on antioxidant parameter activities in different tissues.