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Abstract Title:

The effect of lycopene on hepatotoxicity of aflatoxin B1 in rats.

Abstract Source:

Arch Physiol Biochem. 2019 Aug 5:1-8. Epub 2019 Aug 5. PMID: 31378089

Abstract Author(s):

Aysegul Karaca, Seval Yilmaz, Emre Kaya, Serdar Altun

Article Affiliation:

Aysegul Karaca

Abstract:

Oxidative damage caused by aflatoxin (AF) in rat liver tissue and the inhibition effect of lycopene against this injury was investigated. Groups were formed as; control group (not treated), lycopene group (5 mg/kg/day, gavage for 15 days), AFB1 group (0.5 mg/kg/day, gavage for 7 days) and AFB1 + lycopene group. Lycopene administered simultaneously with AFB1. It was observed significant increase in malondialdehyde level, decrease in glutathione level, antioxidant enzyme activities in liver tissue of AFB1 group when compared with control group. It was determined to significantly increase in plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase activities in AFB1 group when compared with control group. It was determined significant decrease in malondialdehyde level,plasma aspartate transaminase, alanine transaminase, lactate dehydrogenase activities and increase in glutathione level, antioxidant enzyme activities in AFB1 + lycopene group when compared with AFB1 group. This study suggests that lycopene which has antioxidant properties can be prevented fromAFB1 induced hepatotoxicity.

Study Type : Animal Study

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