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Article Publish Status: FREE
Abstract Title:

Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.

Abstract Source:

Molecules. 2012 Apr 20 ;17(4):4672-83. Epub 2012 Apr 20. PMID: 22522397

Abstract Author(s):

Bendong Chen, Mingliang Ning, Guangshun Yang

Article Affiliation:

Bendong Chen

Abstract:

The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.

Study Type : Animal Study

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