Article Publish Status: FREE
Abstract Title:

Effect of Phlorofucofuroeckol A and Dieckol Extracted fromon Noise-induced Hearing Loss in a Mouse Model.

Abstract Source:

Mar Drugs. 2021 Aug 1 ;19(8). Epub 2021 Aug 1. PMID: 34436282

Abstract Author(s):

Hyunjun Woo, Min-Kyung Kim, Sohyeon Park, Seung-Hee Han, Hyeon-Cheol Shin, Byeong-Gon Kim, Seung-Ha Oh, Myung-Whan Suh, Jun-Ho Lee, Moo-Kyun Park

Article Affiliation:

Hyunjun Woo


One of the well-known causes of hearing loss is noise. Approximately 31.1% of Americans between the ages of 20 and 69 years (61.1 million people) have high-frequency hearing loss associated with noise exposure. In addition, recurrent noise exposure can accelerate age-related hearing loss. Phlorofucofuroeckol A (PFF-A) and dieckol, polyphenols extracted from the brown alga, are potent antioxidant agents. In this study, we investigated the effect of PFF-A and dieckol on the consequences of noise exposure in mice. In 1,1-diphenyl-2-picrylhydrazyl assay, dieckol and PFF-A both showed significant radical-scavenging activity. The mice were exposed to 115 dB SPL of noise one single time for 2 h. Auditory brainstem response(ABR) threshold shifts 4 h after 4 kHz noise exposure in mice that received dieckol were significantly lower than those in the saline with noise group. The high-PFF-A group showed a lower threshold shift at click and 16 kHz 1 day after noise exposure than the control group. The high-PFF-A group also showed higher hair cell survival than in the control at 3 days after exposure in the apical turn. These results suggest that noise-induced hair cell damage in cochlear and the ABR threshold shift can be alleviated by dieckol and PFF-A in the mouse. Derivatives of these compounds may be applied to individuals who are inevitably exposed to noise, contributing to the prevention of noise-induced hearing loss with a low probability of adverse effects.

Study Type : Animal Study

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