Abstract Title:

[The effect of probiotics on the secretory immunity of saliva in patients with type 2 diabetes].

Abstract Source:

Stomatologiia (Mosk). 2019 ;98(6):26-29. PMID: 31922506

Abstract Author(s):

M E Malyshev, A K Iordanishvili, O V Prisyazhnyuk, A O Bumai

Article Affiliation:

M E Malyshev


To study the effect of the use of probiotics on the state of mucosal immunity in patients with type 2 diabetes. Evaluation of the results was carried out based on immunological parameters of the saliva of 50 patients suffering from type 2 diabetes with moderate periodontitis, before and 1 month after taking a probiotic complex based on Lactobacillus. In the salivary fluid of patients, a decrease in the concentration of pro-inflammatory cytokines IL-1β, TNF-α and IL-8 was noted, while an increase in the anti-inflammatory cytokine IL-10 was observed. An increase in local mucosal immunity was also observed, manifested in an increase in the synthesis of secretory immunoglobulin A.

Study Type : Human Study

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