Effect of treatment with carvacrol and aerobic training on cardiovascular function in spontaneously hypertensive rats.
Exp Physiol. 2021 Feb 17. Epub 2021 Feb 17. PMID: 33595154
Herikson Araujo Costa
NEW FINDINGS: What is the central question of this study?
ABSTRACT: Systemic arterial hypertension is considered the foremost cardiovascular risk factor, and it is necessary to examine different therapies that help prevent and treat it, especially when associated with other cardiovascular risk factors. In this context, it is known that both carvacrol and aerobic physical training benefit the cardiovascular system. This study investigated the effects of treatment with carvacrol combined with aerobic exercise on hypertensive rats with cardiovascular risk parameters. We used an experimental design and six groups: normotensive control (Wistar), hypertensive control (SHR), positive control treated with amlodipine (Aml-20mg), treated with carvacrol (Carv-20mg), trained with exercise (Exer), and treated with carvacrol (ExerCarv). The treatment lasted for four weeks, monitoring heart rate and systolic blood pressure (SBP) measurements. At the end of the treatment, vascular reactivity tests were performed in addition to biochemical measurements of urea, creatinine, AST, ALT, triglycerides, total cholesterol, HDL-C, LDL-C, VLDL-C, atherogenic indexes, relative heart weight, and histopathological analysis of cardiac perivascular tissue. Significant reductions in SBP were observed after the training period, with ExerCarv showing a greater magnitude of reduction (∆ SBP = 88 ± 10.0 mmHg, 42%). This group also experienced reductions in atherogenic indices and improvement in all analysed lipid parameters, with no differences observed in the Exer group. Findings indicated that the interaction between aerobic exercise and carvacrol offers a greater BP reduction, which is particularly efficient for controlling biochemical parameters of cardiovascular risk, regardless of carvacrol use. This article is protected by copyright. All rights reserved.