Article Publish Status: FREE
Abstract Title:

Effect of Turmacin supplementation on joint discomfort and functional outcome among healthy participants - A randomized placebo-controlled trial.

Abstract Source:

Complement Ther Med. 2020 Sep ;53:102522. Epub 2020 Jul 22. PMID: 33066856

Abstract Author(s):

Jeffrey Pradeep Raj, Shreeraam Venkatachalam, Pranathi Racha, Sreejith Bhaskaran, Rajkumar S Amaravati

Article Affiliation:

Jeffrey Pradeep Raj


OBJECTIVE: Curcuma longa has been widely used in Ayurveda for its medicinal properties and Turmacin was developed from C. longa as a standardized extract containing turmerosaccharides. In this clinical trial, the effect of Turmacin on knee joint discomfort in healthy adults subjected to strenuous physical activity was evaluated.

DESIGN: Double-blind, triple-arm, parallel-group, randomized placebo-controlled trial.

SETTING: Healthy participants from an urban tertiary care teaching hospital.

INTERVENTION: Healthy participants were randomized in 1:1:1 ratio to receive either Turmacin 0.5 g/1 g or placebo once daily for 84 days. The participants were subjected to 10-minute strenuous exercise.

OUTCOME MEASURES: Time to initial pain, final pain score on a visual analogue scale, range of movement (ROM) of knee and the force of contractions of muscles around the knee joint.

RESULTS: A total of n = 90 participants were recruited. The mean final pain scores were significantly lower in the Turmacin 1 g and Turmacin 0.5 g when compared with the placebo from day-7 and day-5 onwards respectively. The survival analysis consistently showed a decreased hazard for early onset of pain in boththe Turmacin groups. On day-84, the difference in mean ROM between Turmacin 0.5 g and placebo was 4.79 degrees (p = 0.008) and that for Turmacin 1 g and placebo was 2.34 degrees (p = 0.306). The difference in muscle force for isokinetic contractions of the quadriceps at angular velocities of 120 and 180 was significant between Turmacin 0.5 g and placebo (p = 0.002 and p = 0.005 respectively) while that for Turmacin 1 g&Turmacin 0.5 g (p = 0.206 and p = 0.414 respectively) and Turmacin 1 g&Placebo (p = 0.046 and p = 0.037) were not significant. However, in the within group analysis participants in Turmacin 1 g group had better preserved muscle functions than Turmacin 0.5 g group at angular velocities of 120 and 180 when compared with placebo.

CONCLUSION: Turmacin (0.5 g and 1 g) was efficacious when compared to placebo in increasing the pain threshold and knee ROM in healthy participants with minor adverse events.

Study Type : Human Study
Additional Links
Therapeutic Actions : Exercise : CK(4855) : AC(736)
Pharmacological Actions : Analgesics : CK(3498) : AC(646)

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