Effectiveness ofExtract in the Treatment of Corrosive Esophageal Burns.
J Invest Surg. 2021 May 17:1-6. Epub 2021 May 17. PMID: 33998353
PURPOSE: The purpose of our study is to determine the effectiveness of "" extract in corrosive esophageal burns and to shed light on the search for new treatments.
MATERIALS AND METHODS: A total of 32 Sprague Dawley rats were separated into 4 groups. A standard esophageal burn model was created. Group 1 was identified as the sham group. Group 2 was burned and no treatment was performed afterward. Group 3 was burned and then 2 cc/dayextract was given for 21 days. Group 4 was not applied any process and 2 cc/dayextract was given for 21 days. The rats were sacrificed and biopsy specimens were taken for histopathological examination for the presence of inflammation, fibrosis, and necrosis.
RESULTS: There was a significant difference between groups in terms of inflammation, fibrosis, and necrosis. Furthermore, in the bilateral comparisons between the groups, there was a meaningful difference in terms of inflammation and fibrosis between Group 2 and Group 3. However, there was no meaningful difference between the same groups in terms of necrosis.
CONCLUSION: extract may be effective on inflammation, fibrosis, and necrosis in corrosive esophageal burns.