Abstract Title:

The effects of black seed supplementation on cardiovascular risk factors in patients with nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled clinical trial.

Abstract Source:

Phytother Res. 2019 Jul 10. Epub 2019 Jul 10. PMID: 31293021

Abstract Author(s):

Mina Darand, Zahra Darabi, Zahra Yari, Mehdi Hedayati, Mohammad Amin Shahrbaf, Ahmad Khoncheh, Behnam Hosseini-Ahangar, Seyed Moayyed Alavian, Azita Hekmatdoost

Article Affiliation:

Mina Darand


Nonalcoholic fatty liver disease (NAFLD) is highly related to cardiovascular disorders risk factors. This study aimed to evaluate the effects of black seed (Nigella sativa) supplementation on cardiovascular disorders risk factors in patients with NAFLD. This randomized, double-blind, placebo-controlled clinical trial was conducted on 50 patients with NAFLD. Participants were assigned to receive a lifestyle modification plus 2 g/day of either N. sativa or placebo for 12 weeks. Compared with the placebo, N. sativa supplementation led to significant reductions in serum glucose (-7.95 vs. -1.22; p = .041), serum insulin (-3.87 vs. -1.07; p = .027), homeostatic model of assessment for insulin resistance (-1.02 vs. -0.28; p = .021), and a significant increase in quantitative insulin sensitivity check index (0.03 vs. 0.006; p = .002). All of these changes were remained significant after adjusting for known confounding variables; however, there was no significant difference in lipid profile changes between thetwo groups (p = .05). N. sativa supplementation significantly decreased hepatic steatosis percentage compared with the placebo after adjustment for confounding variables (p = .005). In conclusion, our results indicate that daily intake of 2-g N. sativa plus lifestyle modification is superiorto lifestyle modification alone in amelioration of insulin resistance and hepatic steatosis in patients with NAFLD.

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