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Abstract Title:

The effects of electronic cigarette vapor on placental trophoblast cell function.

Abstract Source:

Reprod Toxicol. 2018 10 ;81:115-121. Epub 2018 Jul 23. PMID: 30048688

Abstract Author(s):

Sergio Raez-Villanueva, Christina Ma, Sarah Kleiboer, Alison C Holloway

Article Affiliation:

Sergio Raez-Villanueva

Abstract:

Despite evidence that maternal smoking is associated with numerous adverse outcomes, 10-35% of women still smoke during pregnancy. Recently, many smokers have turned to electronic cigarettes (e-cigarettes) as a smoking cessation tool. However, there is considerable uncertainty regarding their safety for use during pregnancy. The goal of this study was to examine the effects of e-cigarette vapour on placental trophoblast function. HTR-8/SVneo cells were exposed to unflavored e-cigarette vapour-conditioned media with and without nicotine to assess cell viability, proliferation, migration (wound healing assay), invasion (transwell extracellular matrix invasion assay), and tube formation, a surrogate for angiogenesis. While there was no effect on cell viability, proliferation or migration (all p > 0.05), e-cigarette conditioned media significantly reduced trophoblast invasion and tube formation; these effects could not be solely attributed to the presence of nicotine. These results suggest that an evaluation of the safety of e-cigarette use during pregnancy is urgently required.

Study Type : In Vitro Study

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Sayer Ji
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