Abstract Title:

Effects of fucoxanthin on autophagy and apoptosis in SGC-7901cells and the mechanism.

Abstract Source:

J Cell Biochem. 2018 Sep ;119(9):7274-7284. Epub 2018 May 15. PMID: 29761894

Abstract Author(s):

Yue Zhu, Jing Cheng, Zhenli Min, Tingzi Yin, Rong Zhang, Wei Zhang, Ling Hu, Zhiwen Cui, Chengzhi Gao, Shiqiang Xu, Chunxiang Zhang, Xiamin Hu

Article Affiliation:

Yue Zhu


Autophagy and apoptosis are involved in the development of a variety of cancers. Fucoxanthin is a natural compound known to have antitumor effects, so we aimed to explore its effects on autophagy and apoptosis in gastric cancer SGC7901 cells. Specifically, we performed methyl thiazolyl tetrazolium assay, transmission electron microscopy, real-time polymerase chain reaction, Western blot analysis, immunofluorescence assay, and cell apoptosis analysis to clarify the role of fucoxanthin in SGC-7901 cells. Our results indicate that fucoxanthin significantly inhibits the viability of SGC-7901 cells, effectively inducing both autophagy and apoptosis by up-regulating the expressions of beclin-1, LC3, and cleaved caspase-3 (CC3), and by down regulating Bcl-2. Fucoxanthin-induced autophagy also seems to occur before, and may promote apoptosis.

Study Type : In Vitro Study

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Sayer Ji
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