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Abstract Title:

Effects of garlic supplementation on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.

Abstract Source:

Phytother Res. 2020 Aug ;34(8):1947-1955. Epub 2020 Mar 5. PMID: 32135032

Abstract Author(s):

Asieh Panjeshahin, Mehdi Mollahosseini, Monireh Panbehkar-Jouybari, Mojtaba Kaviani, Farhang Mirzavandi, Mahdieh Hosseinzadeh

Article Affiliation:

Asieh Panjeshahin

Abstract:

Current evidence on the beneficial effects of garlic on liver enzymes is contradictory. Therefore, the aim of this systematic review and meta-analysis is to evaluate the effect of garlic supplementation on human liver enzymes, such as Alanine Transaminase (ALT/SGPT) and Aspartate Transaminase (AST/SGOT). To collect the required data, PubMed, Scopus, ISI Web of Science, and Google scholar databases were systematically searched from inception to June 2019. A meta-analysis was conducted using the random-effects model to evaluate the effects of garlic supplementation on ALT and AST levels. The Cochran's Q-test and inconsistency index were also used to evaluate heterogeneity among the studies. Among a total of 15,514 identified articles, six studies (containing 301 participants) met the inclusion criteria. Results of the meta-analysis showed that garlic supplementation significantly decreased AST level (Hedges' g = -0.36, 95% confidence interval [CI]: -0.72, -0.004, p = .047); whereas, it had no significant effect on ALT level (Hedges' g = -0.22, 95% CI: -0.64, 0.20, p = .310). Results showed that garlic supplementation reduced AST levels significantly; however, had no significant effect on ALT levels. Further studies are still needed to confirm the results.

Study Type : Meta Analysis, Review
Additional Links
Pharmacological Actions : Hepatoprotective : CK(5098) : AC(2264)

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