The effects of hesperidin on stricture formation in corrosive esophageal burns. - GreenMedInfo Summary
The effects of hesperidin on stricture formation in corrosive esophageal burns: an experimental study.
Esophagus. 2021 Jul 26. Epub 2021 Jul 26. PMID: 34312811
AIM/BACKGROUND: Esophageal strictures in children that develop as a result of accidental ingestion of corrosive substances remain an important health problem. The purpose of this study is to determine the effects of Hesperidin, an effective bioflavonoid in the proliferative and exudative phase of inflammation, on the stricture formation in corrosive esophageal burns.
METHODS: Experimental esophageal burns in rats were created using a modified Gehanno and Guedon model with 20% NaOH. Rats were divided into 5 groups. In the Sham group, the distal esophagus was prepared and cannulated according to the model, but no NaOH was administrated. The esophageal burn was created with NaOH in the other groups. The burned groups were divided into two groups as untreated (T, T) and treated with 100 mg/kg/day Hesperidin (H, H) intraperitoneally, and these groups were divided into two according to their sacrification periods (14 and 21 days). Inflammation, fibrosis, and necrosis were graded by histopathological evaluation in all groups. The efficacy of treatment was evaluated using the weight of rats, stenosis index, and histopathological parameters.
RESULTS: Histopathologic damage scores such as inflammation, necrosis, and fibrosis were lower in the Hand Hgroups and higher in the Tand Tgroups. And also stenosis index was found higher in Tand Tgroups (p < 0.05), while it was similar to the Sham group in Hand Hgroups. No statistically significant difference was found between the Hand Hgroups in terms of stenosis index. When weights of the rats at the beginning and end of the experiment were compared, weights of the Hand Hgroups and the Sham group were similar. There was a significant decrease in the weight of the rats in the Tand Tgroups (p < 0.001).
CONCLUSIONS: This study is the first to use Hesperidin in preventing esophageal damage in an esophageal caustic burn model. It was shown that Hesperidin was effective in reducing macroscopic and microscopic histopathologic damage in the corrosive esophageal burn model, preventing the stricture formation, and has positive effects on nutrition in rats with an esophageal burn.