The effects of Hippophae rhamnoides in neuroprotection and behavioral alterations against iron-induced epilepsy.
Epilepsy Res. 2021 Sep ;175:106695. Epub 2021 Jun 24. PMID: 34186382
Epilepsy is a neurological disorder in which malfunctioning of the electrical activity of the brain causes recurrent, unprovoked seizures. Epilepsy causes wide symptoms that include cognitive dysfunction, anxiety, behavioral alterations, and histological impairments. In this study, the effect of Hippophae rhamnoides (Sea buckthorn/Sbt) on electrophysiology, behavior, and histology in iron-induced epilepsy was analyzed. Rats were randomly divided into four groups (n = 8); Control group, Epileptic group, Sbt treated epileptic group, and Sbt treated group. To induce epilepsy, the intracortical iron injection was administered at a dose of 5μl of 100 mM FeCl. A signiﬁcant increase in epileptiform activity, behavioral abnormalities, and histological impairments was observed in the iron-induced epileptic rats. Hippophae rhamnoides berry extract was administered orally at a dose of 1 ml/kg body wt. for one month. Sbt administration significantly reduced the epileptiform activity, improved behavioral abnormalities, and improved histological impairments in epileptic rats. In conclusion, this study demonstrates the antiepileptic effect of Sbt that probably has exerted by its neuroprotective and behavioral alteration potential against iron-induced epilepsy.