Abstract Title:

The effects of photobiomodulation on inflammatory infiltrate during muscle repair in advanced-age rats.

Abstract Source:

J Gerontol A Biol Sci Med Sci. 2019 Mar 20. Epub 2019 Mar 20. PMID: 30891589

Abstract Author(s):

Evaldo Moreira da Silva, Raquel Agnelli Mesquita-Ferrari, Maria Fernanda Setúbal Destro Rodrigues, Eric Moreno Ramos Magalhães, Sandra Kalil Bussadori, Adriana de Brito, Felipe de Moura Messias, Nadhia Helena Costa Souza, Agnelo Neves Alves, Kristianne Porta Santos Fernandes

Article Affiliation:

Evaldo Moreira da Silva


Photobiomodulation (PBM) enhances muscle repair in aged animals, but its effect on the modulation of the phenotype of immune cells has not yet been determined. Rats (20-month-old) were submitted to cryoinjury of the tibialis anterior muscle and were treated with PBM. After 1, 3 and 7 days, the muscles were submitted to immunohistochemical analysis for the determination of neutrophils and macrophage phenotypes. The muscles treated with PBM exhibited a smaller number of neutrophils after one day of treatment and a greater number of both M1 and M2 macrophages after three days of treatment. The irradiated tissues exhibited a smaller amount of both macrophage phenotypes after seven days of treatment. PBM produced temporal alterations in the phenotype of the inflammatory cells during muscle repair process in advanced-age animals, indicating that these mechanisms may contribute to the beneficial effects of this therapy in the treatment of muscle injuries.

Study Type : Animal Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.