Abstract Title:

[Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells].

Abstract Source:

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2009 Aug ;25(8):678-80. PMID: 19664387

Abstract Author(s):

Zhi-jun Yu, Li-ya He, Yong Chen, Mian-yun Wu, Xue-hua Zhao, Zhen-yu Wang

Article Affiliation:

Zhi-jun Yu

Abstract:

AIM: To investigate the mechanism of quercetin on the inhibition of the lymphatic metastasis in human gastric cancer cells MGC-803.

METHODS: Cells were divided into the control group and the quercetin (Que)-treated group. Immunohistochemistry and RT-PCR were used to detect the expression of vascular endothelial growth factor C (VEGF-C) and VEGFR-3 of human gastric cancer cells MGC-803 in response to Que.

RESULTS: Que significantly decreased the expression of VEGF-C and VEGFR-3 at 40 mumol/L compared with the control group after 48 h (P<0.01).

CONCLUSION: Que can down-regulate the expression of VEGF-C and VEGFR-3 in human gastric cancer cells MGC-803.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : VEGFR3 inhibition : CK(12) : AC(3)

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Sayer Ji
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