Effects of Thymoquinone on radiation enteritis in mice. - GreenMedInfo Summary
Effects of Thymoquinone on radiation enteritis in mice.
Sci Rep. 2018 Oct 11 ;8(1):15122. Epub 2018 Oct 11. PMID: 30310156
Radiation enteritis is an old but emerging question induced by the application of radiation. However, no effective drugs for radiation enteritis in clinic. In this study, we found that thymoquinone (TQ) could mitigate intestinal damages induced by irradiation. After exposure to irradiation, TQ-treated improved the irradiated mice survival rate, ameliorated intestinal injury and increased the numbers of intestinal crypts. Furthermore, Lgr5ISCs and their daughter cells, including Vil1enterocytes, Ki67cells and lysozymePaneth cells, were all significantly increased with TQ treatment. In addition, P53,γH2AX, caspase8, caspase9 and caspase3 expression were all reduced by TQ. Our data showed that TQ modulated DNA damages and decreased the apoptosis in the small intestine. TQ might be used for radiation enteritis treatment.