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Abstract Title:

Effects of Vitamin D Deficiency on Proliferation and Autophagy of Ovarian and Liver Tissues in a Rat Model of Polycystic Ovary Syndrome.

Abstract Source:

Biomolecules. 2019 Sep 10 ;9(9). Epub 2019 Sep 10. PMID: 31509973

Abstract Author(s):

Krisztina Lajtai, Csilla Terézia Nagy, Róbert Tarszabó, Rita Benkő, Leila Hadjadj, Réka Eszter Sziva, Dóra Gerszi, Bálint Bányai, Péter Ferdinandy, György László Nádasy, Zoltán Giricz, Eszter Mária Horváth, Szabolcs Várbíró

Article Affiliation:

Krisztina Lajtai

Abstract:

AIM: We aimed to examine the alterations of the insulin signaling pathway, autophagy, nitrative stress and the effect of vitamin D supplementation in the liver and ovaries of vitamin D deficient hyperandrogenic rats.

METHODS: Female Wistar rats received eight weeks of transdermal testosterone treatment and lived on a low vitamin D diet (D-T+). Vitamin D supplementation was achieved by oral administration of vitamin D3 (D+T+). Sham-treated (D+T-) and vitamin D deficient animals (D-T-) served as controls. (N = 10-12 per group).

RESULTS: D-T+ animals showed decreased LC3 II levels in the liver and increased p-Akt/Akt and p-eNOS/eNOS ratios with decreased insulin receptor staining in the ovaries. Vitamin D supplementation prevented the increase of Akt phosphorylation in the ovaries. Vitamin D deficiency itself also led to decreased LC3 II levels in the liver and decreased insulin receptor staining in the ovaries. D-T+ group showed no increase in nitrotyrosine staining; however, the ovaries of D-T- rats and the liver of D+T+ animals showed increased staining intensity.

CONCLUSION: Vitamin D deficiency itself might lead to disrupted ovarian maturation and autophagy malfunction in the liver. Preventing Akt phosphorylation may contribute to the beneficial effect of vitamin D treatment on ovarian function in hyperandrogenism.

Study Type : Animal Study

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Sayer Ji
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