n/a
Abstract Title:

The efficacy of Alpha-Lipoic Acid in improving oxidative, inflammatory and mood status in women with episodic migraine in a randomized, double-blind, placebo-controlled clinical trial.

Abstract Source:

Int J Clin Pract. 2021 Jun 9:e14455. Epub 2021 Jun 9. PMID: 34105866

Abstract Author(s):

Mahnaz Rezaei Kelishadi, Amirmansour Alavi Naeini, Gholamreza Askari, Fariborz Khorvash, Zahra Heidari

Article Affiliation:

Mahnaz Rezaei Kelishadi

Abstract:

AIM: Migraine is a common neurovascular disorder, which is associated with severe to moderate disabling headaches. Oxidative stress and inflammation might play a role in migraine pathogenesis and the mood disorders. Considering the antioxidant and anti-inflammatory properties of alpha-lipoic acid (ALA), this study was designed to investigate its effect on oxidative, inflammatory and mood conditions in women with episodic migraine.

METHODS: In total 92 women with episodic migraine participated in the study. The patients were randomly divided into two groups, receiving a 300 mg capsule of ALA or placebo twice daily for 3 months. To assess the oxidative and inflammatory status, the serum levels of total antioxidant capacity (TAC), total oxidant status (TOS), glutathione (GSH), malondialdehyde (MDA), oxidative stress index (OSI) and C - reactive protein (CRP) were determined at the beginning and at the end of the intervention. A depression, anxiety, stress scale (DASS-21-items) questionnaire was used to evaluate mood status.

RESULTS: Finally, 79 patients reached the final analysis stage. At the end of the intervention, a significant decrease in the serum levels of MDA (means difference (MD): -0.83, 95% confidence intervals (CI): -1.04,-0.62 nmol/ml vs MD: -0.32, CI: -0.48,-0.15 nmol/ml; P<0.001) and CRP (MD:-0.78, CI: -1.17,-0.39 mg/L vs MD:-0.63, CI: -1.80,0.52 mg/L; P<0.001) was observed in the ALA as compared with the placebo group. But changes in serum GSH (P=0.086), TAC (P=0.068), TOS (P=0.225), and OSI (P=0.404) were not statistically significant. In addition, depression, anxiety, and stress (with p<0.001, in all cases) had significantly decreased in the intervention as compared with the control group.

CONCLUSION: The results of this study suggest that ALA supplementation for 3 months has beneficial effects on improving the oxidative, inflammatory and mood conditions of patients suffering from episodic migraine.

Study Type : Human Study

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.