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Abstract Title:

Effects of epigallocatechin-3-gallate on the HMGB1/RAGE pathway in PM-exposed asthmatic rats.

Abstract Source:

Biochem Biophys Res Commun. 2019 Apr 16. Epub 2019 Apr 16. PMID: 31003767

Abstract Author(s):

YuanZhe Li, LiXia Chen, FeiFei Guo, Yang Cao, Wenjie Hu, Yang Shi, XinChun Lin, Jie Hou, LiPing Li, XianFei Ding, YanJun Guo

Article Affiliation:

YuanZhe Li

Abstract:

Current studies have shown that long-term exposure to fine particulate matter (PM) can aggravate lung injury in asthmatic children. The HMGB1/RAGE pathway may play an important role, but few studies on the HMGB1/RAGE signaling pathway in PM-induced asthma have been performed. Epigallocatechin-3-gallate (EGCG), which has antioxidant, anti-inflammatory and immunomodulatory effects, has not been examined in studies at home and abroad. In this study, we established an animal model of asthma and observed that the lung tissue was damaged, inflammatory cells infiltrated, bronchial wall thickness (WTt) and bronchial smooth muscle thickness (WTm) increased and the HMGB1 and RAGE mRNA and protein expression increased. The asthmatic rats exposed to PMshowed significantly increased lung injury and inflammatory cell infiltration, WTt and WTm further increased, and HMGB1 and RAGE mRNA and protein levels were higher than those in the asthma group. The asthmatic rats exposed to PMwere treated with EGCG, which alleviated the lung injury, reduced the number of inflammatory cells, decreased WTt and WTm, and reduced the expression of HMGB1 and RAGE mRNA and protein. The high-dose group showed more significant effects than the other groups. In conclusion, our results suggest that HMGB1 and RAGE are involved in the pathogenesis of asthma. PMexposure significantly aggravated airway inflammation injury in asthmatic rats. EGCG can reduce lung injury and airway remodeling in PM-exposed asthmatic rats and has lung protective effects. The mechanism may be related to regulation of the HMGB1/RAGE signaling pathway. Our results may provide new ideas and methods for the prevention and treatment of PM-induced asthma.

Study Type : Animal Study

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