Abstract Title:

Differential effects of Epigallocatechin-3-gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model.

Abstract Source:

Mol Nutr Food Res. 2016 Jan 9. Epub 2016 Jan 9. PMID: 26748562

Abstract Author(s):

Irushi Abeysekera, Jared Thomas, Taxiarchis M Georgiadis, Alycia G Berman, Max A Hammond, Karl J Dria, Joseph M Wallace, Randall J Roper

Article Affiliation:

Irushi Abeysekera

Abstract:

SCOPE: Down syndrome (DS), caused by trisomy of human chromosome 21 (Hsa21), is characterized by a spectrum of phenotypes including skeletal abnormalities. The Ts65Dn DS mouse model exhibits similar skeletal phenotypes as humans with DS. DYRK1A, a kinase encoded on Hsa21, has been linked to deficiencies in bone homeostasis in DS mice and individuals with DS. Treatment with Epigallocatechin-3-gallate (EGCG), a known inhibitor of Dyrk1a, improves some skeletal abnormalities associated with DS in mice. EGCG supplements are widely available but the effectiveness of different EGCG-containing supplements have not been well studied.

METHODS AND RESULTS: Six commercially available supplements containing EGCG were analyzed, and two of these supplements were compared with pure EGCG for their impact on skeletal deficits in a DS mouse model. The results demonstrate differential effects of commercial supplements on correcting skeletal abnormalities in Ts65Dn mice. Different EGCG-containing supplements display differences in degradation, polyphenol content and effects on trisomic bone.

CONCLUSIONS: This work suggests that the dose of EGCG and composition of EGCG-containing supplements may be important in correcting skeletal deficits associated with DS. Careful analyses of these parameters may lead to a better understanding of how to improve skeletal and other deficits that impair individuals with DS. This article is protected by copyright. All rights reserved.

Study Type : Animal Study

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