EGCG has a protective effect on rat brain injury induced by middle cerebral artery occlusion. - GreenMedInfo Summary

n/a
Article Publish Status: FREE

Click here to read the complete article.

Abstract Title:

Epigallocatechin-3-Gallate Reduces Neuronal Apoptosis in Rats after Middle Cerebral Artery Occlusion Injury via PI3K/AKT/eNOS Signaling Pathway.

Abstract Source:

Biomed Res Int. 2018 ;2018:6473580. Epub 2018 Mar 25. PMID: 29770336

Abstract Author(s):

Wang Nan, Xu Zhonghang, Chen Keyan, Liu Tongtong, Guo Wanshu, Xu Zhongxin

Article Affiliation:

Wang Nan

Abstract:

Background/Aims: Epigallocatechin-3-gallate (EGCG) has neuroprotective effects and the ability to resist amyloidosis. This study observed the protective effect of EGCG against neuronal injury in rat models of middle cerebral artery occlusion (MCAO) and investigated the mechanism of action of PI3K/AKT/eNOS signaling pathway.

Methods: Rat models of permanent MCAO were established using the suture method. Rat behavior was measured using neurological deficit score. Pathology and apoptosis were measured using HE staining and TUNEL. Oxidative stress and brain injury markers were examined using ELISA. Apoptosis-related proteins and PI3K/AKT/eNOS signaling pathway were determined using western blot assay and immunohistochemistry.

Results: EGCG decreased neurological function score, protected nerve cells, inhibited neuronal apoptosis, and inhibited oxidative stress injury and brain injury markers level after MCAO. EGCG reduced the apoptotic rate of neurons, increased the expression of Bcl-2, and decreased the expression of Caspase-3 and Bax. After LY294002 suppressed the PI3K pathway, the protective effect of EGCG decreased after administration of PI3K inhibitors.

Conclusion: EGCG has a protective effect on rat brain injury induced by MCAO, possibly by modulating the PI3K/AKT/eNOS signaling pathway.

Article Published Date : Dec 31, 2017
Study Type : Animal Study
Additional Links
Substances : EGCG (Epigallocatechin gallate) : CK(1091) : AC(784)
Diseases : Middle Cerebral Artery Occlusion (MCAO) : CK(109) : AC(53)
Pharmacological Actions : Neuroprotective Agents : CK(10404) : AC(6995)

Print Options

Some features are currently member only features. If you are already a member, please login. Otherwise, click here to become a member.
  • Printer-friendly version

Key Research Topics

Substance

EGCG (Epigallocatechin gallate)

Disease

Middle Cerebral Artery Occlusion (MCAO)

Pharmacological Actions

Neuroprotective Agents

Connect with GreenMedInfo

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2024 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.