Green tea (-)-epigallocatechin-3-gallate counteracts daytime overeating induced by high-fat diet in mice.
Mol Nutr Food Res. 2016 Jul 28. Epub 2016 Jul 28. PMID: 27468160
SCOPE: High-fat diet (HFD) induces overeating and obesity. Green tea (-)-epigallocatechin-3-gallate (EGCG) reduces HFD-induced body weight and body fat gain mainly through increased lipid metabolism and fat oxidation. However, little is known about its effect on HFD-induced alterations in feeding behavior.
METHODS AND RESULTS: Three diet groups of wildtype C57B/6j male mice at 5 months old were fed on normal chow diet (NCD), one week of HFD (60% of energy) and three months of HFD (diet-induced obesity, DIO) prior to EGCG supplement in respective diet. EGCG had no effect on feeding behavior in NCD group. Increased daytime feeding induced by HFD was selectively corrected by EGCG treatment in HFD groups, including reversed food intake, feeding frequency and meal size in HFD+EGCG group, and reduced food intake and feeding frequency in DIO+EGCG group. Moreover, EGCG treatment altered diurnally oscillating expression pattern of key appetite-regulating genes, including AGRP, POMC and CART, and key circadian genes Clock and Bmal1 in hypothalamus of DIO mice, indicating its central effect on feeding regulation.
CONCLUSION: Our study demonstrates that EGCG supplement specifically counteracts daytime overeating induced by HFD in mice, suggesting its central role in regulating feeding behavior and energy homeostasis. This article is protected by copyright. All rights reserved.