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Abstract Title:

Electro-acupuncture Protects diabetic nephropathy-induced inflammation through suppression of NLRP3 inflammasome in Renal macrophage isolation.

Abstract Source:

Endocr Metab Immune Disord Drug Targets. 2021 Jan 18. Epub 2021 Jan 18. PMID: 33461476

Abstract Author(s):

Jieying Zhang, Xiao Yang, Xinhuan Zhang, Dan Lu, Rui Guo

Article Affiliation:

Jieying Zhang

Abstract:

BACKGROUND: With the increasing prevalence of diabetes in recent years, diabetic nephropathy (DN) has also become a dangerous disease that greatly endangers human health. The study was designed to determine the mechanism and effect of Electro-acupuncture (EA) in alleviating DN-induced inflammation.

METHODS: Mice were intraperitoneally injected with STZ (streptozotocin, 50 mg/kg, S0130, Sigma, St. Louis, MO, USA) for five consecutive days. After 12 weeks after induction, blood glucose levels were measured (>300 mg/dL).

RESULTS: The serum levels of IL-1β and IL-6 were decreased in EA-treated DN mice, and EA protected renal injury. EA could suppress HMGB1/NLRP3/NF-κB pathway. HMGB1 inhibition increased the anti-inflammatory effects of EA on DN by suppressing NLRP3/NF-κB pathway. The activation of HMGB1 attenuated the anti-inflammatory effects ofEA on DN by inducing NLRP3/NF-κB pathway.

CONCLUSIONS: These results suggested that EA protected DN-induced inflammation through suppression of NLRP3 inflammasome.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Renoprotective : CK(1308) : AC(593)

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