Electromagnetic radiation modulates the ETS oncogene in vivo. - GreenMedInfo Summary
In vivo modulation of ETS genes induced by electromagnetic fields.
In Vivo. 2001 Nov-Dec;15(6):489-94. PMID: 11887334
We have previously shown that electromagnetic field (EMF) exposure induces ETS1 oncogene overexpression in different cell lines. In order to investigate in vivo EMF effects, BALB/c mice were exposed at different times to 50 MHz radiation, modulated (80%) at 16 Hz. The exposed and control animals were sacrificed and the spleen excised for rt-pcr and western blot analysis. We observed an increase in ETS1 mRNA and protein expression, but a decrease in ETS2 protein levels. Preliminary results from this experimental model show in vivo evidence of the effect of EMF on ETS oncogene expression.