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Abstract Title:

The effect of progesterone on the electron emission and degradation of testosterone.

Abstract Source:

Gynecol Endocrinol. 2011 Dec ;27(12):1077-83. Epub 2011 Apr 11. PMID: 21480767

Abstract Author(s):

Nikola Getoff, Heike Schittl, Marion Gerschpacher, Johannes Hartmann, Iren Danielova, Ruth-Maria Quint

Article Affiliation:

Section of Radiation Biology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.

Abstract:

Based on recent findings that hormones can emit electrons () from their excited singlet state in polar media, it was of importance to study a possible mutual interaction of progesterone (PRG) and testosterone (TES) in this respect. Hormones of highest purity were dissolved in an air-free mixture of 40% triply distilled water and 60% ethanol, because the hormones are unsoluble in water. As energy source for substrate excitation in singlet state served a monochromatic UV-light (254 nm), the emitted electrons were scavenged by chloroethanol, whereby the quantum yield of produced Cl⁻ ions, Q (Cl⁻), is equal to Q(e⁻(aq)). Hormone degradation initiated by the electron emission was studied by HPLC method, using a Zorbax Eclipse XDB-C18 column (150 mm x 4.6 mm, 5 μm). The quantum yield of emitted e⁻(aq), Q(e⁻(aq)), from TES was 3.6 times higher than that from PRG, whichis explained by the different molecular structures of the hormones. Observed 2nd and 3rd maxima of electron emission indicate the ability of TES and PRG products to also eject e⁻(aq), but with lower yield. It can be stated that a part of the emitted electrons from TES are consumed by PRG⁺ leading to a partial regeneration of hormone. The present results offer a deeper insight in the biological behavior of hormones.

Study Type : In Vitro Study

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