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Article Publish Status: FREE
Abstract Title:

β-elemene induces glioma cell apoptosis by downregulating survivin and its interaction with hepatitis B X-interacting protein.

Abstract Source:

Oncol Rep. 2012 Dec ;28(6):2083-90. Epub 2012 Sep 11. PMID: 22965456

Abstract Author(s):

Hang Zhang, Feng Xu, Tian Xie, Hongchuan Jin, Liyun Shi

Article Affiliation:

Hang Zhang

Abstract:

β-elemene, extracted from the ginger plant, possesses antitumor activity against a broad range of cancers clinically. However, the mechanism underlying β-elemene-induced cytotoxicity remains incompletely understood. Here, we show that β-elemene promoted apoptotic cell death in human glioma cells, downregulated survivin gene expression, and induced caspase-9, -3 and -7 activities. Induction of apoptosis was associated with inhibition of survivin gene expression, and restoration of survivin levels remarkably attenuated β-elemene-induced glioma cell death. Moreover, we found that the interaction between surviving and HBXIP, a critical regulator of caspase-9 activity, was impaired by β-elemene treatment. The results, therefore, reveal a caspase-mediated apoptotic pathway induced by β-elemene in human glioma cells, which is associated with downregulation of survivin itself and the interaction between survivin and HBXP.

Study Type : In Vitro Study

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Sayer Ji
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