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Article Publish Status: FREE
Abstract Title:

Intravenous Administration of Lycopene, a Tomato Extract, Protects against Myocardial Ischemia-Reperfusion Injury.

Abstract Source:

Nutrients. 2016 ;8(3). Epub 2016 Mar 3. PMID: 26950150

Abstract Author(s):

Chao Tong, Chuan Peng, Lianlian Wang, Li Zhang, Xiaotao Yang, Ping Xu, Jinjin Li, Thibaut Delplancke, Hua Zhang, Hongbo Qi

Article Affiliation:

Chao Tong

Abstract:

BACKGROUND: Oral uptake of lycopene has been shown to be beneficial for preventing myocardial ischemia-reperfusion (I/R) injury. However, the strong first-pass metabolism of lycopene influences its bioavailability and impedes its clinic application. In this study, we determined an intravenous (IV) administration dose of lycopene protects against myocardial infarction (MI) in a mouse model, and investigated the effects of acute lycopene administration on reactive oxygen species (ROS) production and related signaling pathways during myocardial I/R.

METHODS: In this study, we established both in vitro hypoxia/reoxygenation (H/R) cell model and in vivo regional myocardial I/R mouse model by ligating left anterior artery descending. TTC dual staining was used to assess I/R induced MI in the absence and presence of acute lycopene administration via tail vein injection.

RESULTS: Lycopene treatment (1μM) before reoxygenation significantly reduced cardiomyocyte death induced by H/R. Intravenous administration of lycopene to achieve 1 μM concentration in circulating blood significantly suppressed MI, ROS production, and JNK phosphorylation in the cardiac tissue of mice during in vivo regional I/R.

CONCLUSION: Elevating circulating lycopene to 1μM via IV injection protects against myocardial I/R injury through inhibition of ROS accumulation and consequent inflammation in mice.

Study Type : Animal Study, In Vitro Study

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