Ellagic acid can inhibit HIV-1 infection without cytotoxicity. - GreenMedInfo Summary
Ellagic acid inhibits HIV-1 infection in vitro: Potential role as a novel microbicide.
Oral Dis. 2018 Mar ;24(1-2):249-252. PMID: 29480632
OBJECTIVE: To investigate the in vitro effects of ellagic acid on HIV-1 replication.
METHODS: Anti-HIV-1 activity of ellagic acid was determined in vitro using X4-tropic HIV-1and R5-tropic pBaL Env-recombinant virus. Anti-HIV-1activity of ellagic acid was investigated at a multiplicity of infection (MOI) of 0.01. Anti-HIV-1 integrase and protease activities of ellagic acid were tested using in vitro integration and proteolytic cleavage assays.
RESULTS: Ellagic acid, added either before or after HIV-1exposure, suppressed replication of the virus in C8166 cells up to 34%. Ellagic acid showed an anti-integrase ICof 8.7 μM. No cytotoxicity of ellagic acid at concentrations ranging from 12.5 to 100 μM was observed.
CONCLUSION: We conclude that ellagic acid can inhibit HIV-1 infection without cytotoxicity. Thus, it may be a new effective agent that has potential to be developed as a novel microbicide against HIV-1.