Abstract Title:

Emodin in atherosclerosis prevention: Pharmacological actions and therapeutic potential.

Abstract Source:

Eur J Pharmacol. 2020 Oct 1:173617. Epub 2020 Oct 1. PMID: 33010303

Abstract Author(s):

Ning Luo, Jian Fang, LiQin Wei, Amirhossein Sahebkar, Peter J Little, Suowen Xu, ChongBin Luo, GuangNing Li

Article Affiliation:

Ning Luo


Atherosclerotic plaque formation, destabilization and eventual rupture leads to the acute cardiovascular events including myocardial infarction and stroke. Emodin (PubChem CID#3220), (1,3,8-trihydroxy-6-methylanthracene-9,10-dione) is a pharmacologically bioactive constituent isolated from the traditional Chinese medicinal herb Radix rhizoma Rhei. This molecule has anti-oxidant, anti-inflammatory, anti-proliferative, anti-apoptotic and lipid-modulating effects. Experimental studies have demonstrated that emodin attenuates and stabilizes atherosclerotic plaques. In this mini-review, we provide a summary of the pharmacological actions of emodin in regulating vascular function and atherosclerosis, highlighting the therapeutic potential of this phytochemical in patients with cardiovascular disease.

Study Type : In Vitro Study

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