Emodin may improve interstitial fibrosis, thus improving prognosis of lupus nephritis. - GreenMedInfo Summary
[Effect of emodin on fibroblasts in lupus nephritis].
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Mar;20(3):196-8. PMID: 11789284
OBJECTIVE: To observe the effects of emodin on human fibroblasts in culture of kidney in patients with lupus nephritis (LN). METHODS: Fibroblasts were isolated from culture of kidney of LN patients, and the effect of emodin on 3H-TdR incorporated rate of fibroblasts was observed. The apoptosis and c-myc gene expression were detected in the same time by flow cytometry. RESULTS: Emodin could inhibit the proliferation of fibroblasts, and promote the programmed cell death through upregulate c-myc gene expression in human renal fibroblasts. CONCLUSION: Emodin can inhibit proliferation and promote apoptosis of fibroblasts, which may be important in ameliorate interstitial fibrosis, thus improving prognosis of LN.