Abstract Title:

[Effect of emodin on fibroblasts in lupus nephritis].

Abstract Source:

Zhongguo Zhong Xi Yi Jie He Za Zhi. 2000 Mar;20(3):196-8. PMID: 11789284

Abstract Author(s):

G Liu, R Ye, Z Tan

Abstract:

OBJECTIVE: To observe the effects of emodin on human fibroblasts in culture of kidney in patients with lupus nephritis (LN). METHODS: Fibroblasts were isolated from culture of kidney of LN patients, and the effect of emodin on 3H-TdR incorporated rate of fibroblasts was observed. The apoptosis and c-myc gene expression were detected in the same time by flow cytometry. RESULTS: Emodin could inhibit the proliferation of fibroblasts, and promote the programmed cell death through upregulate c-myc gene expression in human renal fibroblasts. CONCLUSION: Emodin can inhibit proliferation and promote apoptosis of fibroblasts, which may be important in ameliorate interstitial fibrosis, thus improving prognosis of LN.

Study Type : Human Study
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