Abstract Title:

[Effect of emodin on hepatocellular apoptosis following orthotopic liver transplantation in rats].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2008 Apr;33(7):809-12. PMID: 18589788

Abstract Author(s):

Sheng-Zhang Lin, Xian-Chou Xu, He Jing, Xiao Yang

Abstract:

OBJECTIVE: To evaluate the effect of emodin on hepatocellular apoptosis following orthotopic liver transplantation (OLT) in rats. METHOD: The LEW --> BN OLT models were established. A total of 24 rats were divided randomly and equally into 4 groups. Group A was treated with normal saline at dose of 0.5 mL x d(-1) intraperitoneally from 1st day to 8 th day after operation. Group B, CsA at dose of 10.0 mg x kg(-1) x d(-1). Group C, emodin at dose of 50.0 mg x kg(-1) x d(-1). Group D, CsA at dose of 10.0 mg x kg(-1) x d(-1) and emodin at dose of 50.0 mg x kg(-1) x d(-1). Fifteen days after operation, rejection active index (RAI) and hepatocellular apoptosis index (AI) was confirmed after observing the pathologic change of transplanted liver in recipients. RESULT: Respectively, the RAI of group A, B, C, D was 7.67 +/- 0.98, 5.17 +/- 0.40, 5.83 +/- 0.75, 3.83 +/- 0.75 and the AI of group A, B, C, D was 35.83 +/- 2.320, 15.83 +/- 1.33, 16.50 +/- 2.35, 11.50 +/- 1.05. The RAI and AI of group B, C, D was significantly lower than group A (P < 0.01) and group D was significantly lower than group B, C too (P < 0.05). There was no significant distinction between group B and C in RAI and AI. CONCLUSION: Emodin has the effect of reduce the hepatocellular apoptosis following OLT in rats and the effect can stronger by CsA.


Study Type : Animal Study

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