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Article Publish Status: FREE
Abstract Title:

Emodin suppresses the migration and invasion of melanoma cells.

Abstract Source:

Biol Pharm Bull. 2021 Mar 17. Epub 2021 Mar 17. PMID: 33731543

Abstract Author(s):

Chi Liu, Liang Chen, Wanchen Wang, Dengke Qin, Chuanlong Jia, Mingjie Yuan, Heng Wang, Yu Guo, Jingjing Zhu, Yiqun Zhou, Haiguang Zhao, Tianyi Liu

Article Affiliation:

Chi Liu

Abstract:

Emodin(1,3,8-trihydroxy-6-methylanthraquinone), as an active ingredient in rhubarb roots and rhizomes, has been reported to possess various pharmacological properties including anti-tumor effects. Recent studies have confirmed that emodin inhibited cell proliferation and induced apoptosis of cancer cells. However, the inhibitory effect of emodin on the migration and invasion of melanoma cells and its underlying mechanism are still unclear. In the study, we observed the impercipient effects of emodin in B16F10 and A375 melanoma cells with strong metastatic abilities, focusing on the functions and mechanisms of migration and invasion of B16F10 and A375 melanoma cells. CCK-8,colony formation test and Annexin V-FITC / PI staining tests confirmed that emodin possessed anti-proliferative and pro-apoptotic activities in B16F10 and A375 cells. The inhibitory effects on the migration and invasion of B16F10 and A375 cells were proved by wound healing assay and Transwell methods. Moreover, immunofluorescence array approved the decrease in protein expression of MMP-2/-9 by emodin, and western blot analyses revealed that emodin could increase the Bax/Bcl-2 radio and inhibit the MMP-2/-9 protein expression and Wnt/β-catenin pathway in a dose-depended manner. BML-284, asan agonist of Wnt/β-catenin signaling pathway, reversed the effects of emodin on cell growth, migration and invasion in B16F10 cells. These findings may suggest that emodin treatment can be a promising therapeutic strategy for melanoma with highly metastatic abilities.

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