Abstract Title:

Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death.

Abstract Source:

J Asian Nat Prod Res. 2019 Jul 25:1-14. Epub 2019 Jul 25. PMID: 31345059

Abstract Author(s):

Yi-Ming Zhang, Xiao-Bing Shi, Bo Xu, Cheng-Shan Yuan, Wei Zheng, Gang Li, Ji Li, Zhen-Hua Wang

Article Affiliation:

Yi-Ming Zhang


Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. Further investigation showed XN inhibited cell proliferation in a time- and dose-dependent manner along with down-regulation of mitogen-activated protein kinase and up-regulation of the endoplasmic reticulum (ER) stress marker Bip, CHOP and protein ubiquitination, which was relieved by the ER-stress inhibitor 4-PBA. Whereas no early apoptosis characteristics was identified during XN induced cell death.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytotoxic : CK(76) : AC(60)

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Sayer Ji
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