Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death.
J Asian Nat Prod Res. 2019 Jul 25:1-14. Epub 2019 Jul 25. PMID: 31345059
Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. Further investigation showed XN inhibited cell proliferation in a time- and dose-dependent manner along with down-regulation of mitogen-activated protein kinase and up-regulation of the endoplasmic reticulum (ER) stress marker Bip, CHOP and protein ubiquitination, which was relieved by the ER-stress inhibitor 4-PBA. Whereas no early apoptosis characteristics was identified during XN induced cell death.