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Article Publish Status: FREE
Abstract Title:

Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape () in the Rat Thoracic Aorta.

Abstract Source:

Evid Based Complement Alternat Med. 2016 ;2016:6846084. Epub 2016 Oct 20. PMID: 27840653

Abstract Author(s):

Sang Keun Ha, Ho-Young Park, Mee-Ra Ryu, Yoonsook Kim, Yongkon Park

Article Affiliation:

Sang Keun Ha

Abstract:

The vasorelaxant effects of dealcoholized wild grape () wine were investigated with isolated rat thoracic aorta. In our present study, we demonstrate that wild grape wine powder (WGWP) induced relaxation of aortic rings preconstricted with norepinephrine in a dose-dependent manner (at concentrations ranging from 0.1 to 1 mg/mL). The vasorelaxant effect of WGWP was dependent on intact endothelia, which was attenuated by incubation with inhibitors of endothelium-derived relaxing factors, such as N-nitro-L-arginine (nitric oxide synthase inhibitor), methylene blue (guanylate cyclase inhibitor), and indomethacin (cyclooxygenase inhibitor). Moreover, treatment with WGWP and atropine (muscarinic receptor antagonist) or diphenylhydramine (histamine receptor antagonist) significantly inhibited endothelium-dependent vasorelaxation. Our results suggest that WGWP induces relaxation in rat aortic rings in an endothelium-dependent manner. Results further indicate that this effect occurs via nitric oxide-cGMP pathway and prostacyclin-cAMP pathway through a muscarinic receptor and histamine receptor.

Study Type : Animal Study

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