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Article Publish Status: FREE
Abstract Title:

Effect of Honey on Diarrhea and Fecal Microbiotain in Critically Ill Tube-Fed Patients: A Single Center Randomized Controlled Study.

Abstract Source:

Anesth Pain Med. 2018 Feb ;8(1):e62889. Epub 2018 Feb 21. PMID: 29868456

Abstract Author(s):

Zahra Vahdat Shariatpanahi, Fatemeh Jamshidi, Javad Nasrollahzadeh, Zohreh Amiri, Houman Teymourian

Article Affiliation:

Zahra Vahdat Shariatpanahi

Abstract:

Background: In patients admitted to the Intensive Care Unit (ICU), Enteral Nutrition (EN) is the first choice for feeding support, however, it is often complicated by gastrointestinal side effects, such as diarrhea. There are no studies that have specifically evaluated effect of a prebiotic, which prevents diarrhea during enteral nutrition.

Objective: This study aimed at evaluating the effect of honey in enteral diet during occurrence of diarrhea and fecal microbiotain in critically ill patients.

Materials and Methods: In this double-blind, randomized controlled single-center study, 32 patients were randomly selected to receive a high protein kitchen enteral diet and the study group had honey as 10% of its carbohydrate intake. Quantitative analyses of bifidobacterium andspecies of fecal samples were assessed by Real-Time Polymerase Chain Reaction (PCR) on days 0 and 7.

Results: Patients in the honey group showed an insignificant increase in the frequency of bifidobacterium DNA by study day 7 in comparison with the control group. In the honey group, there was a considerable reduction in diarrhea (P = 0.09). A significant difference was found in length of Intensive Care Unit (ICU) stay (P = 0.001) and Sequential Organ Failure Assessment (SOFA) score (P = 0.04) in favor of the honey group.

Conclusions: Enteral nutrition with honey might reduce the length of stay at the ICU and development of organ failure in critically ill patients. It seems that honey helps reduce the incidence of diarrhea.

Study Type : Human Study
Additional Links
Pharmacological Actions : Antidiarrheals : CK(110) : AC(20)

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