Article Publish Status: FREE
Abstract Title:

Environmentally Induced Epigenetic Transgenerational Inheritance of Reproductive Disease.

Abstract Source:

Biol Reprod. 2015 Oct 28. Epub 2015 Oct 28. PMID: 26510870

Abstract Author(s):

Eric E Nilsson, Michael K Skinner

Article Affiliation:

Eric E Nilsson


Reproductive disease and fertility issues have dramatically increased in the human population over the last several decades suggesting environmental impacts. Epigenetics provides a mechanistic link by which an organism can respond to environmental factors. Interestingly, environmentally induced epigenetic alterations in the germline can promote aberrant gene expression and disease generationally. Environmentally induced epigenetic transgenerational inheritance is defined as germline transmission of altered epigenetic information between generations in the absence of continued environmental exposures. This form of non-genetic inheritance has been shown to directly influence fertility and reproductive disease. This review describes the studies in a variety of species which impact reproductive disease and abnormalities. Observations suggest serious attention be paid to the possibility that ancestral exposures to environmental insults promotes transgenerational inheritance of reproductive disease susceptibility. Environmentally induced epigenetic transgenerational inheritance appears to be an important contributing factor to reproductive disease in many organisms, including humans.

Study Type : Review

Print Options

Key Research Topics

Sayer Ji
Founder of

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2021, Journal Articles copyright of original owners, MeSH copyright NLM.