Oral Administration of an Enzymatic Protein Hydrolysate from the Green Microalga Chlorella vulgaris Enhances the Nutritional Recovery of Malnourished Mice.
J Med Food. 2011 Jun 11. Epub 2011 Jun 11. PMID: 21663489
1 Center for Studies on Industrial Biotechnology, Faculty of Natural Sciences, University of Oriente , Santiago de Cuba, Cuba .
Abstract This study examined the effects of oral administration of an enzymatic protein hydrolysate from green microalga Chlorella vulgaris (Cv-PH) on the nutritional recovery of malnourished Balb/c mice after a 3-day fasting period. Mice were refed with commercial diet supplemented or not supplemented with Cv-PH (500 mg/kg) for 8 days. Regardless of the diet used during refeeding, animal body weights and serum protein concentrations did not differ between groups. Mice given Cv-PH had a significant increase in hemoglobin concentrations. Most serum amino acid levels were similar in the control and Cv-PH animals. Starved mice refed with Cv-PH showed normal liver functions, as judged by liver weight, protein concentration, and the enzymatic activities of cholinesterase and arginase. Cv-PH increased DNA, protein content, and gut-mucosal weight. In addition, brush-border oligosaccharidase activities were alsohigher in the Cv-PH group. These findings suggest that Chlorella protein hydrolysate can be used to develop specific formulations suitable for pharmacologic nutrition.