Abstract Title:

Epigallocatechin gallate (EGCG) alters body fat and lean mass through sex-dependent metabolic mechanisms in Drosophila melanogaster.

Abstract Source:

Int J Food Sci Nutr. 2019 Apr 22:1-11. Epub 2019 Apr 22. PMID: 31010351

Abstract Author(s):

Phoebe B Chen, Ju Hyeon Kim, Lynnea Young, John M Clark, Yeonhwa Park

Article Affiliation:

Phoebe B Chen


There is increasing interest in the potential role of epigallocatechin gallate (EGCG) in changing body composition to lower body fat with increased lean mass. In this study, we examined the sex-dependent effect of EGCG on body composition, locomotion, feeding behaviour, sugar levels, and transcription levels of key regulators in lipid, carbohydrate, and energy metabolisms in Drosophila melanogaster. EGCG had no effects on body weights in both females and males, but decreased fat accumulation in females compared to the control, accompanied by a reduction in food intake. EGCG treatments increased lean mass and locomotor activity, and downregulated transcription levels of brummer (bmm), adipokinetic hormone (akh), and Drosophila insulin-like peptide 2 (dilp2), and upregulated spargel (srl) in males. In addition, EGCG decreased sugar levels in both females and males. In conclusion, EGCG promotes lean phenotype in D. melanogaster via sex-specific metabolic regulations.

Study Type : Insect Study

Print Options

Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2020 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.