Abstract Title:

Comparative case-control study of homocysteine, vitamin B12, and folic acid levels in patients with epilepsy.

Abstract Source:

Neurologia. 2016 Apr 15. Epub 2016 Apr 15. PMID: 27091678

Abstract Author(s):

L Pulido Fontes, M Pulido Fontes, P Quesada Jiménez, J Muruzabal Pérez, M Mendioroz Iriarte

Article Affiliation:

L Pulido Fontes


INTRODUCTION: Increased blood homocysteine levels are a known cardiovascular risk factor. Epileptic patients on long-term treatment with antiepileptic drugs may present higher homocysteine levels and, consequently, a potential increase in cardiovascular risk.

MATERIAL AND METHODS: We conducted an observational case-control study to compare plasma levels of homocysteine, folic acid, and vitamin B12.

RESULTS: Our study included a total of 88 subjects: 52 patients with epilepsy and 36 controls. Epileptic patients showed higher homocysteine levels (P=.084) and lower levels of folic acid (P<.05).

CONCLUSION: Homocysteine levels should be monitored in epileptic patients on long-term treatment with antiepileptic drugs. We suggest starting specific treatment in patients with high homocysteine levels.

Study Type : Human Study
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