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Abstract Title:

Epstein-Barr virus infection of human brain microvessel endothelial cells: a novel role in multiple sclerosis.

Abstract Source:

J Neuroimmunol. 2011 Jan;230(1-2):173-7. Epub 2010 Sep 9. PMID: 20826008

Abstract Author(s):

Costanza Casiraghi, Katerina Dorovini-Zis, Marc S Horwitz

Article Affiliation:

Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

Abstract:

Multiple sclerosis (MS) is an inflammatory neurological disease that is widely regarded as the outcome of complex interactions between a genetic predisposition and an environmental trigger. Epstein-Barr virus (EBV) has recently been associated with the onset of MS, yet understanding how it elicits autoimmunity remains elusive. Neuroinflammation, including the entry of autoreactive T cells, likely follows a breach of the blood-brain barrier (BBB) leading to CNS lesions in MS. We show that EBV can infect human BBB cells leading to increased production of pro-inflammatory mediators that result in immune cell adherence thus modeling a key step in MS pathogenesis.

Study Type : Review

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Sayer Ji
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