Abstract Title:

Analgesic effect of Nigella sativa seeds extract on experimentally induced pain in albino mice.

Abstract Source:

J Coll Physicians Surg Pak. 2010 Jul ;20(7):464-7. PMID: 20642947

Abstract Author(s):

Muhammad Usman Bashir, Hamid Javaid Qureshi

Article Affiliation:

Muhammad Usman Bashir


OBJECTIVE: To determine the analgesic effect of ethanolic extract of Nigella sativa seeds on experimentally-induced pain in albino mice.

STUDY DESIGN: Randomized controlled trial (RCT).

PLACE AND DURATION OF STUDY: Physiology Department, Services Institute of Medical Sciences (SIMS), Lahore, from May to September, 2009.

METHODOLOGY: The study was carried out in 90 male albino mice using acetic acid induced writhing test as a chemical model of nociception. The mice were divided in three groups of 30 each. Group A was given normal saline (control); group B was given Nigella sativa seed extract in a dose of 50 mg/kg; and group C received diclofenac sodium, as a reference drug. Number of writhings in treated and control groups were compared.

RESULTS: The ethanolic extract of Nigella sativa seeds given intraperitoneally caused significant (p<0.05) analgesic effect on nociceptive response initiated by 0.6% acetic acid; although this analgesic effect was less than that produced by diclofenac sodium.

CONCLUSION: Ethanolic extract of Nigella sativa possessed significant analgesic effect in mice.

Study Type : Animal Study

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