Eucalyptus citriodora essential oil was found to have airborne antituberculosis activity. - GreenMedInfo Summary
Airborne antituberculosis activity of Eucalyptus citriodora essential oil.
J Nat Prod. 2014 Mar 28 ;77(3):603-10. Epub 2014 Mar 18. PMID: 24641242
René F Ramos Alvarenga
The rapid emergence of multi- and extensively drug-resistant tuberculosis (MDR/XDR-TB) has created a pressing public health problem, which mostly affects regions with HIV/AIDS prevalence and represents a new constraint in the already challenging disease management of tuberculosis (TB). The present work responds to the need to reduce the number of contagious MDR/XRD-TB patients, protect their immediate environment, and interrupt the rapid spread by laying the groundwork for an inhalation therapy based on anti-TB-active constituents of the essential oil (EO) of Eucalyptus citriodora. In order to address the metabolomic complexity of EO constituents and active principles in botanicals, this study applied biochemometrics, a 3-D analytical approach that involves high-resolution CCC fractionation, GC-MS analysis, bioactivity measurements, and chemometric analysis. Thus, 32 airborne anti-TB-active compounds were identified in E. citriodora EO: the monoterpenes citronellol (1), linalool (3), isopulegol (5), andα-terpineol (7) and the sesquiterpenoids spathulenol (11), β-eudesmol (23), and τ-cadinol (25). The impact of the interaction of multiple components in EOs was studied using various artificial mixtures (AMxs) of the active monoterpenes 1, 2, and 5 and the inactive eucalyptol (33). Both neat 1 andthe AMx containing 1, 2, and 33 showed airborne TB inhibition of>90%, while the major E. citriodora EO component, 2, was only weakly active, at 18% inhibition.